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How Does Cancer Happen? 

From the National Cancer Institute. A - normal cell division, B - cancer cell division; 1 - apoptosis; 2 - damaged cell. From the National Cancer Institute

• non-lethal genetic damage (mutation)

• acquired or inherited

• clonal expression of a single progenitor cell (i.e. monoclonal)

Cancer Initiation

• for change to be inheritable damaged DNA template must be replicated

• at least one cell cycle of proliferation ’;fixing’; (making permanent) of the mutation

• if cells do not proliferate damaged DNA may be repaired

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